May 15

Integrating Host and Tumor Genome Data Holds Promise for Understanding Cancer Risk

Cancer is a disease of two genomes—the host, or germline genome, and the tumor, or somatic genome—and extensive data have been generated from both genomes. Most studies of cancer risk focus on the germline genome to identify potential cancer risk variants in genome-wide association studies (GWAS). More recently, whole genome or whole exome approaches have …

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Mar 24

How Can We Leverage Existing Resources for Discovery and Validation of Markers for Early Cancer Detection?

Despite the large investment in biomarker discovery and validation, few major early detection cancer biomarkers have been approved for clinical use over the last 25 years. In addition, many initially promising biomarkers have not been validated.  One issue is that biomarker discovery and validation has typically occurred in studies that were initially designed with different …

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Jan 03

We Have Come a Long Way: The 2013 Annual Meeting of the NCI Cohort Consortium

On November 18-19, 2013, the Epidemiology and Genomics Research Program (EGRP) of the Division of Cancer Control and Population Sciences (DCCPS) and the Division of Cancer Epidemiology and Genetics (DCEG) of the National Cancer Institute (NCI) hosted the annual meeting of the NCI Cohort Consortium. More than 140 investigators and researchers, representing over 30 domestic …

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Dec 05

The Continued Importance of Research in Gene-Environment Interactions in 21st Century Epidemiology

Cancer risk is determined by a complex interplay of genetic and environmental factors. To understand this interplay, epidemiologic studies need to consider the effects of gene-environment (GxE) interactions. In 2012, the Epidemiology and Genomics Research Program (EGRP) launched an ongoing effort to transform 21st century epidemiology. Studies of GxE interactions should be part of this …

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Oct 31

A New Resource for Researching the Epidemiology and Genomics of Cancer: CGEN

The Epidemiology and Genomics Research Program (EGRP) at the National Cancer Institute recently launched the Cancer Genomics and Epidemiology Navigator (CGEN), an online resource for the research community. The purpose of CGEN is to assist cancer researchers in navigating existing resources and integrating available information from NCI-funded research projects, publications, and evidenced-based guidelines, and linking …

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Aug 13

Is Integrative Cancer Epidemiology the Next-Gen of Epidemiology?

The National Cancer Institute (NCI) seeks to engage the research community in an ongoing discussion about the future of cancer epidemiology. To date, this discussion has included an NCI workshop, multiple blog posts, and a series of commentaries published in Cancer, Epidemiology, Biomarkers and Prevention. NCI incorporated the insights from these intellectual discourses to develop …

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Jul 03

Shifting the Cancer Research Paradigm: Early-Life Exposures and Cancer Risk Later in Life

Early Life Exposures Banner_1_v2.7-3-13

Most cancer research in human populations has focused on a range of exposures in the middle to last 25th percentile of the lifespan. While this narrow age range yields the highest number of cancer cases, it is a phase of life in which cancer prevention efforts are more difficult and perhaps less effective. The emerging …

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